The goals at the San Paolo stadium in Naples were scored by Lorenzo Insigne (56), Piotr Zielinski (81) and Dries Mertens (83), Ukrinform reports.
In another Group F match, England's Manchester City defeated Feyenoord 1-0.
Standings after five rounds: Manchester City - 15, Shakhtar - 9, Napoli - 6, Feyenoord - 0.
The final round of the Champions League group stage will be held on December 6. Shakhtar will take on Manchester City in Kharkiv, while Feyenoord will face Napoli in Rotterdam. Shaktar Donetsk needs at least a draw to qualify for the Champions League play-offs.
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